Tissue Plasminogen Activator Is Not Involved in Methamphetamine-Induced Neurotoxicity
نویسندگان
چکیده
منابع مشابه
Tissue plasminogen activator mediates amyloid-induced neurotoxicity via Erk1/2 activation.
Tissue plasminogen activator (tPA) is the main activator of plasminogen into plasmin in the brain where it may have beneficial roles but also neurotoxic effects that could be plasmin dependent or not. Little is known about the substrates and pathways that mediate plasmin-independent tPA neurotoxicity. Here we show in primary hippocampal neurons that tPA promotes a catalytic-independent activati...
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ژورنال
عنوان ژورنال: Journal of Pharmacological Sciences
سال: 2008
ISSN: 1347-8613,1347-8648
DOI: 10.1254/jphs.sc0070328